Endocrine Abstracts

The increasing prevalence of obesity is paralleled by related metabolic disorders such as insulin resistance and type 2 diabetes mellitus (T2DM). Extensive efforts across disciplines are made to reveal underlying mechanisms and develop effective therapies against obesity and its comorbidities. Since PET–CT studies provided evidence for functional brown adipose tissue (BAT) in adult humans, this specialized thermogenic compartment of adipocytes is in the focus of current r...

Background: Sleep loss is increasingly common in the western world and has been shown to be associated with an increased risk of diabetes mellitus and obesity.Objective: We hypothesised that short term sleep loss results in a diabetogenic metabolic status during carbohydrate challenge at a breakfast buffet.Subjects and methods: Fifteen healthy, normal-weight young men were studied in randomized balanced order on the subsequent morn...